High-level expression and purification of soluble recombinant FGF21 protein by SUMO fusion in Escherichia coli

BACKGROUND: Fibroblast growth factor 21 (FGF21) is a promising drug candidate to combat metabolic diseases. However, high-level expression and purification of recombinant FGF21 (rFGF21) in Escherichia coli (E. coli) is difficult because rFGF21 forms inclusion bodies in the bacteria making it difficu...

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Main Authors: Wang, Huiyan, Xiao, Yechen, Fu, Lianjun, Zhao, Hongxin, Zhang, Yaofang, Wan, Xiaoshan, Qin, Yuxia, Huang, Yadong, Gao, Hongchang, Li, Xiaokun
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2010
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Research article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2831817/
https://ncbi.nlm.nih.gov/pubmed/20163718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6750-10-14
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