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Mitochondrial biogenesis in epithelial cancer cells promotes breast cancer tumor growth and confers autophagy resistance

Here, we set out to test the novel hypothesis that increased mitochondrial biogenesis in epithelial cancer cells would “fuel” enhanced tumor growth. For this purpose, we generated MDA-MB-231 cells (a triple-negative human breast cancer cell line) overexpressing PGC-1α and MitoNEET, which are establi...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Salem, Ahmed F., Whitaker-Menezes, Diana, Howell, Anthony, Sotgia, Federica, Lisanti, Michael P.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Landes Bioscience 2012
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3524213/
https://ncbi.nlm.nih.gov/pubmed/23070475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.22376
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