Tumor Development, Growth Characteristics and Spectrum of Genetic Aberrations in the TH-MYCN Mouse Model of Neuroblastoma

BACKGROUND: The TH-MYCN transgenic neuroblastoma model, with targeted MYCN expression to the developing neural crest, has been used to study neuroblastoma development and evaluate novel targeted tumor therapies. METHODS: We followed tumor development in 395 TH-MYCN (129X1/SvJ) mice (125 negative, 20...

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Main Authors: Rasmuson, Agnes, Segerström, Lova, Nethander, Maria, Finnman, Jennie, Elfman, Lotta H. M., Javanmardi, Niloufar, Nilsson, Staffan, Johnsen, John Inge, Martinsson, Tommy, Kogner, Per
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3524187/
https://ncbi.nlm.nih.gov/pubmed/23284678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0051297
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