Conditionally reprogrammed cells represent a stem-like state of adult epithelial cells

The combination of irradiated fibroblast feeder cells and Rho kinase inhibitor, Y-27632, conditionally induces an indefinite proliferative state in primary mammalian epithelial cells. These conditionally reprogrammed cells (CRCs) are karyotype-stable and nontumorigenic. Because self-renewal is a rec...

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Bibliographic Details
Main Authors: Suprynowicz, Frank A., Upadhyay, Geeta, Krawczyk, Ewa, Kramer, Sarah C., Hebert, Jess D., Liu, Xuefeng, Yuan, Hang, Cheluvaraju, Chaitra, Clapp, Phillip W., Boucher, Richard C., Kamonjoh, Christopher M., Randell, Scott H., Schlegel, Richard
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2012
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3523865/
https://ncbi.nlm.nih.gov/pubmed/23169653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1213241109
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