The Human Papillomavirus Type 16 E5 Oncoprotein Inhibits Epidermal Growth Factor Trafficking Independently of Endosome Acidification

The human papillomavirus type 16 E5 oncoprotein (16E5) enhances acute, ligand-dependent activation of the epidermal growth factor receptor (EGFR) and concomitantly alkalinizes endosomes, presumably by binding to the 16-kDa “c” subunit of the V-ATPase proton pump (16K) and inhibiting V-ATPase functio...

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Detalhes bibliográficos
Main Authors: Suprynowicz, Frank A., Krawczyk, Ewa, Hebert, Jess D., Sudarshan, Sawali R., Simic, Vera, Kamonjoh, Christopher M., Schlegel, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2950579/
https://ncbi.nlm.nih.gov/pubmed/20686024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00831-10
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