Conditionally reprogrammed cells represent a stem-like state of adult epithelial cells

The combination of irradiated fibroblast feeder cells and Rho kinase inhibitor, Y-27632, conditionally induces an indefinite proliferative state in primary mammalian epithelial cells. These conditionally reprogrammed cells (CRCs) are karyotype-stable and nontumorigenic. Because self-renewal is a rec...

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Bibliografiska uppgifter
Huvudupphovsmän: Suprynowicz, Frank A., Upadhyay, Geeta, Krawczyk, Ewa, Kramer, Sarah C., Hebert, Jess D., Liu, Xuefeng, Yuan, Hang, Cheluvaraju, Chaitra, Clapp, Phillip W., Boucher, Richard C., Kamonjoh, Christopher M., Randell, Scott H., Schlegel, Richard
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2012
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3523865/
https://ncbi.nlm.nih.gov/pubmed/23169653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1213241109
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