Conditionally reprogrammed cells represent a stem-like state of adult epithelial cells

The combination of irradiated fibroblast feeder cells and Rho kinase inhibitor, Y-27632, conditionally induces an indefinite proliferative state in primary mammalian epithelial cells. These conditionally reprogrammed cells (CRCs) are karyotype-stable and nontumorigenic. Because self-renewal is a rec...

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Detalhes bibliográficos
Main Authors: Suprynowicz, Frank A., Upadhyay, Geeta, Krawczyk, Ewa, Kramer, Sarah C., Hebert, Jess D., Liu, Xuefeng, Yuan, Hang, Cheluvaraju, Chaitra, Clapp, Phillip W., Boucher, Richard C., Kamonjoh, Christopher M., Randell, Scott H., Schlegel, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3523865/
https://ncbi.nlm.nih.gov/pubmed/23169653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1213241109
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