Conditionally reprogrammed cells represent a stem-like state of adult epithelial cells

The combination of irradiated fibroblast feeder cells and Rho kinase inhibitor, Y-27632, conditionally induces an indefinite proliferative state in primary mammalian epithelial cells. These conditionally reprogrammed cells (CRCs) are karyotype-stable and nontumorigenic. Because self-renewal is a rec...

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Bibliographische Detailangaben
Hauptverfasser: Suprynowicz, Frank A., Upadhyay, Geeta, Krawczyk, Ewa, Kramer, Sarah C., Hebert, Jess D., Liu, Xuefeng, Yuan, Hang, Cheluvaraju, Chaitra, Clapp, Phillip W., Boucher, Richard C., Kamonjoh, Christopher M., Randell, Scott H., Schlegel, Richard
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2012
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3523865/
https://ncbi.nlm.nih.gov/pubmed/23169653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1213241109
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