Affinity-Based Probes Based on Type II Kinase Inhibitors

Protein kinases are key components of most mammalian signal transduction networks and are therapeutically relevant drug targets. Efforts to study protein kinase function would benefit from new technologies that are able to profile kinases in complex proteomes. Here, we describe active site-directed...

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Autores principales: Ranjitkar, Pratistha, Perera, Gayani K., Swaney, Danielle, Hari, Sanjay B., Larson, Eric T., Krishnamurty, Ratika, Merritt, Ethan A., Villén, Judit, Maly, Dustin J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3523701/
https://ncbi.nlm.nih.gov/pubmed/23088519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja306035v
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