CD4 binding determinant mimicry for HIV vaccine design

The immunodominant epitopes expressed by the HIV-1 envelope protein gp120 are hypermutable, defeating attempts to develop an effective HIV vaccine. Targeting the structurally conserved gp120 determinant that binds host CD4 receptors (CD4BD) and initiates infection is a more promising route to vaccin...

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Bibliografiska uppgifter
Huvudupphovsmän: Nishiyama, Yasuhiro, Planque, Stephanie, Hanson, Carl V., Massey, Richard J., Paul, Sudhir
Materialtyp: Artigo
Språk:Inglês
Publicerad: Frontiers Media S.A. 2012
Ämnen:
Immunology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3523313/
https://ncbi.nlm.nih.gov/pubmed/23251137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2012.00383
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