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Tuning the Structural Coupling between the Transmembrane and Cytoplasmic Domains of Phospholamban to Control Sarcoplasmic Reticulum Ca(2+)-ATPase (SERCA) Function
Phospholamban (PLN) is the endogenous inhibitor of the sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA), the integral membrane enzyme responsible for 70% of the Ca(2+) shuttling into the SR, inducing cardiac muscle relaxation in humans. Dysfunctions in SERCA:PLN interactions have been implicated a...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3522752/ https://ncbi.nlm.nih.gov/pubmed/22971924 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10974-012-9319-4 |
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