Lipid-Mediated Folding/Unfolding of Phospholamban as a Regulatory Mechanism for the Sarcoplasmic Reticulum Ca(2+)-ATPase

The integral membrane protein complex between phospholamban (PLN) and sarcoplasmic reticulum Ca(2+)-ATPase (SERCA) regulates cardiac contractility. In the unphosphorylated form, PLN binds SERCA and inhibits Ca(2+) flux. Upon phosphorylation of PLN at Ser16, the inhibitory effect is reversed. Althoug...

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Hlavní autoři: Gustavsson, Martin, Traaseth, Nathaniel J., Karim, Christine B., Lockamy, Elizabeth L., Thomas, David D., Veglia, Gianluigi
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3573877/
https://ncbi.nlm.nih.gov/pubmed/21419777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.03.015
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