Residual Expression of Reprogramming Factors Affects the Transcriptional Program and Epigenetic Signatures of Induced Pluripotent Stem Cells

Delivery of the transcription factors Oct4, Klf4, Sox2 and c-Myc via integrating viral vectors has been widely employed to generate induced pluripotent stem cell (iPSC) lines from both normal and disease-specific somatic tissues, providing an invaluable resource for medical research and drug develop...

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Main Authors: Sommer, Cesar A., Christodoulou, Constantina, Gianotti-Sommer, Andreia, Shen, Steven S., Sailaja, Badi Sri, Hezroni, Hadas, Spira, Avrum, Meshorer, Eran, Kotton, Darrell N., Mostoslavsky, Gustavo
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
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Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3522693/
https://ncbi.nlm.nih.gov/pubmed/23272148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0051711
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