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Zinc-finger nuclease mediated disruption of Rag1 in the LEW/Ztm rat
BACKGROUND: Engineered zinc-finger nucleases (ZFN) represented an innovative method for the genome manipulation in vertebrates. ZFN introduced targeted DNA double strand breaks (DSB) and initiated non-homologous end joining (NHEJ) after pronuclear or cytoplasmatic microinjection into zygotes. Result...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
BioMed Central
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3522011/ https://ncbi.nlm.nih.gov/pubmed/23136839 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2172-13-60 |
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