Mechanical Strain Downregulates C/EBPβ in MSC and Decreases Endoplasmic Reticulum Stress

Exercise prevents marrow mesenchymal stem cell (MSC) adipogenesis, reversing trends that accompany aging and osteoporosis. Mechanical input, the in-vitro analogue to exercise, limits PPARγ expression and adipogenesis in MSC. We considered whether C/EBPβ might be mechanoresponsive as it is upstream t...

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Autores principales: Styner, Maya, Meyer, Mark B., Galior, Kornelia, Case, Natasha, Xie, Zhihui, Sen, Buer, Thompson, William R., Pike, John Wesley, Rubin, Janet
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3520924/
https://ncbi.nlm.nih.gov/pubmed/23251594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0051613
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