Hexachlorophene Is a Potent KCNQ1/KCNE1 Potassium Channel Activator Which Rescues LQTs Mutants

The voltage-gated KCNQ1 potassium channel is expressed in cardiac tissues, and coassembly of KCNQ1 with an auxiliary KCNE1 subunit mediates a slowly activating current that accelerates the repolarization of action potential in cardiomyocytes. Mutations of KCNQ1 genes that result in reduction or loss...

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Bibliographic Details
Main Authors: Zheng, Yueming, Zhu, Xuejing, Zhou, Pingzheng, Lan, Xi, Xu, Haiyan, Li, Min, Gao, Zhaobing
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3520906/
https://ncbi.nlm.nih.gov/pubmed/23251633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0051820
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