Pharmacokinetic modeling of P-glycoprotein function at the rat and human blood–brain barriers studied with (R)-[(11)C]verapamil positron emission tomography

BACKGROUND: This study investigated the influence of P-glycoprotein (P-gp) inhibitor tariquidar on the pharmacokinetics of P-gp substrate radiotracer (R)-[(11)C]verapamil in plasma and brain of rats and humans by means of positron emission tomography (PET). METHODS: Data obtained from a preclinical...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Müllauer, Julia, Kuntner, Claudia, Bauer, Martin, Bankstahl, Jens P, Müller, Markus, Voskuyl, Rob A, Langer, Oliver, Syvänen, Stina
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer 2012
Schlagworte:
Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3520775/
https://ncbi.nlm.nih.gov/pubmed/23072492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2191-219X-2-58
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