A GWAS sequence variant for platelet volume marks an alternative DNM3 promoter in megakaryocytes near a MEIS1 binding site

We recently identified 68 genomic loci where common sequence variants are associated with platelet count and volume. Platelets are formed in the bone marrow by megakaryocytes, which are derived from hematopoietic stem cells by a process mainly controlled by transcription factors. The homeobox transc...

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Autori principali: Nürnberg, Sylvia T., Rendon, Augusto, Smethurst, Peter A., Paul, Dirk S., Voss, Katrin, Thon, Jonathan N., Lloyd-Jones, Heather, Sambrook, Jennifer G., Tijssen, Marloes R., Italiano, Joseph E., Deloukas, Panos, Gottgens, Berthold, Soranzo, Nicole, Ouwehand, Willem H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2012
Soggetti:
Platelets and Thrombopoiesis
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3520622/
https://ncbi.nlm.nih.gov/pubmed/22972982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-01-401893
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