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Discovery of indole tetrafluorophenoxymethylketone-based potent novel small molecule inhibitors of caspase-3
BACKGROUND: Caspase-3 inhibition has been demonstrated to be therapeutically effective in moderating excessive programmed cell death. Interest in caspase-3 as a therapeutic target has led many to pursue the development of inhibitors. To date, only a few series of non-peptide inhibitors have been des...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3519673/ https://ncbi.nlm.nih.gov/pubmed/22794498 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2191-2858-2-27 |
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