Bulbispermine: A Crinine-Type Amaryllidaceae Alkaloid Exhibiting Cytostatic Activity towards Apoptosis-Resistant Glioma Cells

The Amaryllidaceae alkaloid bulbispermine was derivatized to produce a small group of synthetic analogues. These, together with bulbispermine’s natural crinine-type congeners, were evaluated in vitro against a panel of cancer cell lines with various levels of resistance to proapoptotic stimuli. Bulb...

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Main Authors: Luchetti, Giovanni, Johnston, Robert, Mathieu, Véronique, Lefranc, Florence, Hayden, Kathryn, Andolfi, Anna, Lamoral-Theys, Delphine, Reisenauer, Mary R., Champion, Cody, Pelly, Stephen C., van Otterlo, Willem A. L., Magedov, Igor V., Kiss, Robert, Evidente, Antonio, Rogelj, Snezna, Kornienko, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3519447/
https://ncbi.nlm.nih.gov/pubmed/22389235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201100608
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