Lycorine, the Main Phenanthridine Amaryllidaceae Alkaloid, Exhibits Significant Anti-Tumor Activity in Cancer Cells that Display Resistance to Proapoptotic Stimuli: an Investigation of Structure-Activity Relationship and Mechanistic Insight

Twenty-two lycorine-related compounds were investigated for in vitro anti-tumor activity using four cancer cell lines displaying different levels of resistance to pro-apoptotic stimuli and two cancer cell lines sensitive to pro-apoptotic stimuli. Lycorine and six of its congeners exhibited potency i...

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Detalhes bibliográficos
Main Authors: Lamoral-Theys, Delphine, Andolfi, Anna, Van Goietsenoven, Gwendoline, Cimmino, Alessio, Le Calvé, Benjamin, Wauthoz, Nathalie, Mégalizzi, Véronique, Gras, Thierry, Bruyère, Céline, Dubois, Jacques, Mathieu, Véronique, Kornienko, Alexander, Kiss, Robert, Evidente, Antonio
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3205972/
https://ncbi.nlm.nih.gov/pubmed/19788245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm901031h
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