Synthesis and SAR of 1-Hydroxy-1H-benzo[d]imidazol-2(3H)-ones as Inhibitors of d-Amino Acid Oxidase

[Image: see text] A series of 1-hydroxy-1H-benzo[d]imidazol-2(3H)-ones were synthesized and evaluated for their ability to inhibit human and porcine forms of d-amino acid oxidase (DAAO). The inhibitory potency is largely dependent on the size and position of substituents on the benzene ring with IC(...

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Detalhes bibliográficos
Main Authors: Berry, James F., Ferraris, Dana V., Duvall, Bridget, Hin, Niyada, Rais, Rana, Alt, Jesse, Thomas, Ajit G., Rojas, Camilo, Hashimoto, Kenji, Slusher, Barbara S., Tsukamoto, Takashi
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2012
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3519437/
https://ncbi.nlm.nih.gov/pubmed/23243487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300212a
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