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Diabetes accelerates retinal ganglion cell dysfunction in mice lacking sigma receptor 1

PURPOSE: Sigma receptor 1 (σR1) is a non-opioid transmembrane protein that may act as a molecular chaperone at the endoplasmic reticulum–mitochondrial membrane. Ligands for σR1, such as (+)-pentazocine [(+)-PTZ], confer marked retinal neuroprotection in vivo and in vitro. Recently we analyzed the re...

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Hlavní autoři: Ha, Yonju, Saul, Alan, Tawfik, Amany, Zorrilla, Eric P., Ganapathy, Vadivel, Smith, Sylvia B.
Médium: Artigo
Jazyk:Inglês
Vydáno: Molecular Vision 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3519370/
https://ncbi.nlm.nih.gov/pubmed/23233788
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