Diabetes accelerates retinal ganglion cell dysfunction in mice lacking sigma receptor 1

PURPOSE: Sigma receptor 1 (σR1) is a non-opioid transmembrane protein that may act as a molecular chaperone at the endoplasmic reticulum–mitochondrial membrane. Ligands for σR1, such as (+)-pentazocine [(+)-PTZ], confer marked retinal neuroprotection in vivo and in vitro. Recently we analyzed the re...

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Autores principales: Ha, Yonju, Saul, Alan, Tawfik, Amany, Zorrilla, Eric P., Ganapathy, Vadivel, Smith, Sylvia B.
Formato: Artigo
Lenguaje:Inglês
Publicado: Molecular Vision 2012
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3519370/
https://ncbi.nlm.nih.gov/pubmed/23233788
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