PKCα Activation of p120-catenin Serine 879 Phospho-Switch Disassembles VE-cadherin Junctions and Disrupts Vascular Integrity

RATIONALE: Adherens junctions (AJs) are the primary intercellular junctions in microvessels responsible for endothelial barrier function. Homophilic adhesion of vascular endothelial (VE) cadherin forms AJs, which are stabilized by binding of p120-catenin (p120). p120 dissociation from VE-cadherin re...

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Autores principales: St Amant, Emily Vandenbroucke, Tauseef, Mohammad, Vogel, Stephen M., Gao, Xiao-Pei, Mehta, Dolly, Komarova, Yulia, Malik, Asrar B.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3518422/
https://ncbi.nlm.nih.gov/pubmed/22798526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.112.269654
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