Evidence of a common mechanism of disassembly of adherens junctions through Gα13 targeting of VE-cadherin

The heterotrimeric G protein Gα13 transduces signals from G protein–coupled receptors (GPCRs) to induce cell spreading, differentiation, migration, and cell polarity. Here, we describe a novel GPCR-independent function of Gα13 in regulating the stability of endothelial cell adherens junctions (AJs)....

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Main Authors: Gong, Haixia, Gao, Xiaopei, Feng, Shaoting, Siddiqui, M. Rizwan, Garcia, Alexander, Bonini, Marcelo G., Komarova, Yulia, Vogel, Stephen M., Mehta, Dolly, Malik, Asrar B.
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2014
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3949568/
https://ncbi.nlm.nih.gov/pubmed/24590762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20131190
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