Viral Diversity Threshold for Adaptive Immunity in Prokaryotes

Bacteria and archaea face continual onslaughts of rapidly diversifying viruses and plasmids. Many prokaryotes maintain adaptive immune systems known as clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated genes (Cas). CRISPR-Cas systems are genomic sensors that se...

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Main Authors: Weinberger, Ariel D., Wolf, Yuri I., Lobkovsky, Alexander E., Gilmore, Michael S., Koonin, Eugene V.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Microbiology 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3517865/
https://ncbi.nlm.nih.gov/pubmed/23221803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00456-12
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