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Evolutionary Dynamics of the Prokaryotic Adaptive Immunity System CRISPR-Cas in an Explicit Ecological Context

A stochastic, agent-based mathematical model of the coevolution of the archaeal and bacterial adaptive immunity system, CRISPR-Cas, and lytic viruses shows that CRISPR-Cas immunity can stabilize the virus-host coexistence rather than leading to the extinction of the virus. In the model, CRISPR-Cas i...

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Detalles Bibliográficos
Autores principales: Iranzo, Jaime, Lobkovsky, Alexander E., Wolf, Yuri I., Koonin, Eugene V.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2013
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754601/
https://ncbi.nlm.nih.gov/pubmed/23794616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00412-13
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