Depletion of Endothelial or Smooth Muscle Cell-Specific Angiotensin II Type 1a Receptors Does Not Influence Aortic Aneurysms or Atherosclerosis in LDL Receptor Deficient Mice

BACKGROUND: Whole body genetic deletion of AT1a receptors in mice uniformly reduces hypercholesterolemia and angiotensin II-(AngII) induced atherosclerosis and abdominal aortic aneurysms (AAAs). However, the role of AT1a receptor stimulation of principal cell types resident in the arterial wall rema...

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Bibliographic Details
Main Authors: Rateri, Debra L., Moorleghen, Jessica J., Knight, Victoria, Balakrishnan, Anju, Howatt, Deborah A., Cassis, Lisa A., Daugherty, Alan
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3517567/
https://ncbi.nlm.nih.gov/pubmed/23236507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0051483
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