Subcutaneous Angiotensin II Infusion using Osmotic Pumps Induces Aortic Aneurysms in Mice

Osmotic pumps continuously deliver compounds at a constant rate into small animals. This article introduces a standard protocol used to induce aortic aneurysms via subcutaneous infusion of angiotensin II (AngII) from implanted osmotic pumps. This protocol includes calculation of AngII amount and dis...

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Detalles Bibliográficos
Publicado en:J Vis Exp
Main Authors: Lu, Hong, Howatt, Deborah A., Balakrishnan, Anju, Moorleghen, Jessica J., Rateri, Debra L., Cassis, Lisa A., Daugherty, Alan
Formato: Artigo
Idioma:Inglês
Publicado: MyJove Corporation 2015
Assuntos:
Medicine
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4692630/
https://ncbi.nlm.nih.gov/pubmed/26436287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3791/53191
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