Amlodipine Reduces AngII-Induced Aortic Aneurysms and Atherosclerosis in Hypercholesterolemic Mice

BACKGROUND: The purpose of this study was to determine effects of amlodipine, a dihydropyridine calcium channel blocker, on development of angiotensin II (AngII)-induced vascular pathologies. METHODS AND RESULTS: Male LDL receptor -/- mice were infused with vehicle, amlodipine (5 mg/kg/d), AngII (1,...

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Detalhes bibliográficos
Main Authors: Chen, Xiaofeng, Rateri, Debra L., Howatt, Deborah A., Balakrishnan, Anju, Moorleghen, Jessica J., Morris, Andrew J., Charnigo, Richard, Cassis, Lisa A., Daugherty, Alan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3828247/
https://ncbi.nlm.nih.gov/pubmed/24244746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0081743
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