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Direct Association of Unfolded Proteins with Mammalian ER Stress Sensor, IRE1β
IRE1, an ER-localized transmembrane protein, plays a central role in the unfolded protein response (UPR). IRE1 senses the accumulation of unfolded proteins in its luminal domain and transmits a signal to the cytosolic side through its kinase and RNase domains. Although the downstream pathways mediat...
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| Autores principales: | , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3517461/ https://ncbi.nlm.nih.gov/pubmed/23236464 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0051290 |
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