A two-step strategy for SAR studies of N- methylated Aβ42 C-terminal fragments as Aβ42 toxicity inhibitors

Neurotoxic Aβ42 oligomers are believed to be the main cause of Alzheimer’s disease. Previously, we found that the C-terminal fragments (CTFs), Aβ(30–42) and Aβ(31–42) were the most potent inhibitors of Aβ42 oligomerization and toxicity in a series of Aβ(x–42) peptides, (x=28–39). Therefore, we chose...

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Bibliographic Details
Main Authors: Li, Huiyuan, Zemel, Reeve, Lopes, Dahabada H. J., Monien, Bernhard H., Bitan, Gal
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3517043/
https://ncbi.nlm.nih.gov/pubmed/22307963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201100584
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