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Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing
Antibody VRC01 is a human immunoglobulin that neutralizes about 90% of HIV-1 isolates. To understand how such broadly neutralizing antibodies develop, we used x-ray crystallography and 454 pyrosequencing to characterize additional VRC01-like antibodies from HIV-1–infected individuals. Crystal struct...
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Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2011
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3516815/ https://ncbi.nlm.nih.gov/pubmed/21835983 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1207532 |
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