miR-218 Directs a Wnt Signaling Circuit to Promote Differentiation of Osteoblasts and Osteomimicry of Metastatic Cancer Cells

MicroRNAs (miRNAs) negatively and post-transcriptionally regulate expression of multiple target genes to support anabolic pathways for bone formation. Here, we show that miR-218 is induced during osteoblast differentiation and has potent osteogenic properties. miR-218 promotes commitment and differe...

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Detalhes bibliográficos
Main Authors: Hassan, Mohammad Q., Maeda, Yukiko, Taipaleenmaki, Hanna, Zhang, Weibing, Jafferji, Mohammad, Gordon, Jonathan A. R., Li, Zhaoyong, Croce, Carlo M., van Wijnen, Andre J., Stein, Janet L., Stein, Gary S., Lian, Jane B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3516754/
https://ncbi.nlm.nih.gov/pubmed/23060446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.377515
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