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N-Sulfation of Heparan Sulfate Regulates Early Branching Events in the Developing Mammary Gland

Branching morphogenesis, a fundamental process in the development of epithelial organs (e.g. breast, kidney, lung, salivary gland, prostate, pancreas), is in part dependent on sulfation of heparan sulfate proteoglycans. Proper sulfation is mediated by biosynthetic enzymes, including exostosin-2 (Ext...

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Autors principals: Bush, Kevin T., Crawford, Brett E., Garner, Omai B., Nigam, Kabir B., Esko, Jeffrey D., Nigam, Sanjay K.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3516752/
https://ncbi.nlm.nih.gov/pubmed/23060443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.423327
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