N-Sulfation of Heparan Sulfate Regulates Early Branching Events in the Developing Mammary Gland

Branching morphogenesis, a fundamental process in the development of epithelial organs (e.g. breast, kidney, lung, salivary gland, prostate, pancreas), is in part dependent on sulfation of heparan sulfate proteoglycans. Proper sulfation is mediated by biosynthetic enzymes, including exostosin-2 (Ext...

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Библиографические подробности
Главные авторы: Bush, Kevin T., Crawford, Brett E., Garner, Omai B., Nigam, Kabir B., Esko, Jeffrey D., Nigam, Sanjay K.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2012
Предметы:
Glycobiology and Extracellular Matrices
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3516752/
https://ncbi.nlm.nih.gov/pubmed/23060443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.423327
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