Rhesus Macaque Theta Defensins Suppress Inflammatory Cytokines and Enhance Survival in Mouse Models of Bacteremic Sepsis

Theta-defensins (θ-defensins) are macrocyclic antimicrobial peptides expressed in leukocytes of Old World monkeys. The peptides are broad spectrum microbicides in vitro and numerous θ-defensin isoforms have been identified in granulocytes of rhesus macaques and Olive baboons. Several mammalian α- an...

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Main Authors: Schaal, Justin B., Tran, Dat, Tran, Patti, Ösapay, George, Trinh, Katie, Roberts, Kevin D., Brasky, Kathleen M., Tongaonkar, Prasad, Ouellette, André J., Selsted, Michael E.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3516535/
https://ncbi.nlm.nih.gov/pubmed/23236475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0051337
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