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Endoproteolytic Activity of the Proteasome
The proteasome plays a central role in the degradation of regulatory and misfolded proteins. Current models suggest that substrates access the internal catalytic sites by processively threading their termini through the gated substrate channel. Here, we found that latent (closed) and activated (open...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3516294/ https://ncbi.nlm.nih.gov/pubmed/12481023 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1079293 |
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