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Accelerated formation of α-synuclein oligomers by concerted action of the 20S proteasome and familial Parkinson mutations
A hallmark of Parkinson disease (PD) is the formation of intracellular protein inclusions called Lewy bodies that also contain mitochondria. α-Synuclein (αSyn) is a major protein component of Lewy bodies, where it is in an amyloid conformation and a significant fraction is truncated by poorly unders...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3266686/ https://ncbi.nlm.nih.gov/pubmed/20148295 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10863-009-9258-y |
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