ATP Binding and ATP Hydrolysis Play Distinct Roles in the Function of 26S Proteasome

The 26S proteasome degrades polyubiquitinated proteins by an energy-dependent mechanism. Here we define multiple roles for ATP in 26S proteasome function. ATP binding is necessary and sufficient for assembly of 26S proteasome from 20S proteasome and PA700/19S subcomplexes and for proteasome activati...

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Main Authors: Liu, Chang-Wei, Li, Xiaohua, Thompson, David, Wooding, Kerry, Chang, Tsui-ling, Tang, Zhanyun, Yu, Hongtao, Thomas, Philip J., DeMartino, George N.
Format: Artigo
Jezik:Inglês
Izdano: 2006
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3951175/
https://ncbi.nlm.nih.gov/pubmed/17018291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2006.08.025
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