TPP1 OB-fold domain controls telomere maintenance by recruiting telomerase to chromosome ends

Telomere synthesis in cancer cells and stem cells involves trafficking of telomerase to Cajal bodies, and telomerase is thought to be recruited to telomeres through interactions with telomere-binding proteins. Here, we show that the OB-fold domain of the telomere-binding protein TPP1 recruits telome...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Zhong, Franklin L., Batista, Luis F.Z., Freund, Adam, Pech, Matthew F., Venteicher, Andrew S., Artandi, Steven E.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2012
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3516183/
https://ncbi.nlm.nih.gov/pubmed/22863003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.07.012
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