Intermediate state trapping of a voltage sensor

Voltage sensor domains (VSDs) regulate ion channels and enzymes by undergoing conformational changes depending on membrane electrical signals. The molecular mechanisms underlying the VSD transitions are not fully understood. Here, we show that some mutations of I241 in the S1 segment of the Shaker K...

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Main Authors: Lacroix, Jérôme J., Pless, Stephan A., Maragliano, Luca, Campos, Fabiana V., Galpin, Jason D., Ahern, Christopher A., Roux, Benoît, Bezanilla, Francisco
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3514728/
https://ncbi.nlm.nih.gov/pubmed/23183699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201210827
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