A heterozygous IDH1(R132H/WT) mutation induces genome-wide alterations in DNA methylation

Monoallelic point mutations of the NADP(+)-dependent isocitrate dehydrogenases IDH1 and IDH2 occur frequently in gliomas, acute myeloid leukemias, and chondromas, and display robust association with specific DNA hypermethylation signatures. Here we show that heterozygous expression of the IDH1(R132H...

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Autors principals: Duncan, Christopher G., Barwick, Benjamin G., Jin, Genglin, Rago, Carlo, Kapoor-Vazirani, Priya, Powell, Doris R., Chi, Jen-Tsan, Bigner, Darell D., Vertino, Paula M., Yan, Hai
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2012
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3514664/
https://ncbi.nlm.nih.gov/pubmed/22899282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.132738.111
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