Vesicular Uptake Blockade Generates the Toxic Dopamine Metabolite 3,4-Dihydroxyphenylacetaldehyde in PC12 Cells: Relevance to the Pathogenesis of Parkinson Disease

Parkinson disease entails profound loss of nigrostriatal dopaminergic terminals, decreased vesicular uptake of intra-neuronal catecholamines, and relatively increased putamen tissue concentrations of the toxic dopamine metabolite, 3,4-dihydroxyphenylacetaldehyde (DOPAL). The objective of this study...

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Hauptverfasser: Goldstein, David S., Sullivan, Patti, Cooney, Adele, Jinsmaa, Yunden, Sullivan, Rachel, Gross, Daniel J., Holmes, Courtney, Kopin, Irwin J., Sharabi, Yehonatan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3514596/
https://ncbi.nlm.nih.gov/pubmed/22906103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2012.07924.x
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