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Design and characterization of a protein superagonist of IL-15 fused with IL-15Rα and a high-affinity T cell receptor

To avoid high systemic doses, strategies involving antigen-specific delivery of cytokine via linked antibodies or antibody fragments have been employed. Targeting cancer-associated peptides presented by MHC molecules (pepMHC) increases the number of potential target antigens, and takes advantage of...

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Detalhes bibliográficos
Main Authors: Stone, Jennifer D., Chervin, Adam S., Schreiber, Hans, Kranz, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3514595/
https://ncbi.nlm.nih.gov/pubmed/22961781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/btpr.1631
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