Ad5:Ad48 Hexon Hypervariable Region Substitutions Lead to Toxicity and Increased Inflammatory Responses Following Intravenous Delivery

The development of adenoviral vectors for intravascular (i.v.) delivery will require improvements to their in vivo safety and efficacy. The hypervariable regions (HVRs) of the Ad5 hexon are a target for neutralizing antibodies, but also interact with factor X (FX), facilitating hepatocyte transducti...

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Detalhes bibliográficos
Main Authors: Coughlan, Lynda, Bradshaw, Angela C, Parker, Alan L, Robinson, Hollie, White, Katie, Custers, Jerome, Goudsmit, Jaap, Van Roijen, Nico, Barouch, Dan H, Nicklin, Stuart A, Baker, Andrew H
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3514487/
https://ncbi.nlm.nih.gov/pubmed/22929662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.162
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