Ad5:Ad48 Hexon Hypervariable Region Substitutions Lead to Toxicity and Increased Inflammatory Responses Following Intravenous Delivery

The development of adenoviral vectors for intravascular (i.v.) delivery will require improvements to their in vivo safety and efficacy. The hypervariable regions (HVRs) of the Ad5 hexon are a target for neutralizing antibodies, but also interact with factor X (FX), facilitating hepatocyte transducti...

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Bibliographic Details
Main Authors: Coughlan, Lynda, Bradshaw, Angela C, Parker, Alan L, Robinson, Hollie, White, Katie, Custers, Jerome, Goudsmit, Jaap, Van Roijen, Nico, Barouch, Dan H, Nicklin, Stuart A, Baker, Andrew H
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2012
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3514487/
https://ncbi.nlm.nih.gov/pubmed/22929662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.162
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