Ad5:Ad48 Hexon Hypervariable Region Substitutions Lead to Toxicity and Increased Inflammatory Responses Following Intravenous Delivery

The development of adenoviral vectors for intravascular (i.v.) delivery will require improvements to their in vivo safety and efficacy. The hypervariable regions (HVRs) of the Ad5 hexon are a target for neutralizing antibodies, but also interact with factor X (FX), facilitating hepatocyte transducti...

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Autores principales: Coughlan, Lynda, Bradshaw, Angela C, Parker, Alan L, Robinson, Hollie, White, Katie, Custers, Jerome, Goudsmit, Jaap, Van Roijen, Nico, Barouch, Dan H, Nicklin, Stuart A, Baker, Andrew H
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2012
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3514487/
https://ncbi.nlm.nih.gov/pubmed/22929662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.162
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