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Identification of collagen binding domain residues that govern catalytic activities of matrix metalloproteinase-2 (MMP-2)

An innovative approach to enhance the selectivity of matrix metalloproteinase (MMP) inhibitors comprises targeting these inhibitors to catalytically required substrate binding sites (exosites) that are located outside the catalytic cleft. In MMP-2, positioning of collagen substrate molecules occurs...

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Detalhes bibliográficos
Main Authors: Mikhailova, Margarita, Xu, Xiaoping, Robichaud, Trista K., Pal, Sanjay, Fields, Gregg B., Steffensen, Bjorn
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3513585/
https://ncbi.nlm.nih.gov/pubmed/23085623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.matbio.2012.10.001
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